Sonic The Hedgehog (1991)
Sonic The Hedgehog 1991 is the most well known game released on the SEGA Genesis/Mega Drive. It has had numerous ports over the years as well as countless fan projects.
The best way to play Sonic The Hedgehog 1991 is the original Genesis/Mega Drive release, which has been ported to various systems and collections over the years. Many of said re-releases have emulation inaccuracies, and it is recommended to use a genesis/mega drive emulator or original hardware to play.
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Alternatively there is a decompilation of the 2013 android port, which has since been ported to various platforms. Including backporting of Sonic's new moves. Widescreen, and other basic QoL.
Additionally there is a fan made edit of this decomp that adds further QoL, A seventh chaos emerald, Super Sonic and a laundry list of other features.